Is Epithalon an approved medicine?

No. It has not been approved by any regulator, and there are no controlled human trials. We supply it as a research chemical for laboratory use only.

What has Epithalon research looked at?

Cell studies of telomerase and gene expression and a small number of animal studies, much of it from one research group. The cited studies are above.

A synthetic tetrapeptide (Ala-Glu-Asp-Gly, AEDG) modelled on a pineal-gland peptide.

Epithalon research: what the studies have looked at

This page summarises the published research on Epithalon, for reference. It states what each study investigated and in what model, not an effect in people, and it is not medical advice. Epithalon is not an approved medicine; what we supply is a research chemical for laboratory use only.

What Epithalon is

Epithalon, also written Epitalon, is a synthetic tetrapeptide (the sequence Ala-Glu-Asp-Gly, or AEDG) modelled on a peptide from the pineal gland. It is not an approved drug. Two things are worth knowing about the evidence before the studies: it is almost entirely in cells and animals, and a large share of it comes from one research group in Russia, which is a limit on how far it can be generalised.

What the studies investigated

Khavinson et al. (2003), Bulletin of Experimental Biology and Medicine 135(6):590-592. In vitro, human fibroblasts. Investigated the effect of the peptide on telomerase activity and telomere length in cultured cells Source.

Anisimov et al. (2003), Biogerontology 4(4):193-202. Mice. Investigated the effect of the peptide on lifespan measures and tumour incidence in a mouse strain Source.

Khavinson et al. (2020), Molecules 25(3):609. In vitro, human mesenchymal stem cells. Investigated the peptide’s reported effects on cultured stem cells Source.

Mechanism, as described in the literature

The proposed mechanisms in the literature centre on telomerase activity and gene expression, reported in cultured cells and in a small number of animal studies. These are laboratory findings from a narrow set of sources, not established human effects, and no controlled human trial supports the claims that circulate about the peptide.

The material we supply

We supply Epithalon as a research chemical, released against a written specification with a batch certificate of analysis. It is not a medicine and is not for human or animal use. For the vial sizes, the price per mg and how to order, see the Epithalon compound page; the COA lookup pulls the certificate for any batch. The references above link to each study’s record; this summary is for research and educational reference only.