Is AOD-9604 an approved medicine?

No. Human obesity trials did not demonstrate efficacy, it is not approved, and it is prohibited by the World Anti-Doping Agency. We supply it for laboratory use only.

What did AOD-9604 human research find?

Human obesity trials did not demonstrate the weight effect they set out to measure; the earlier positive work was in obese rodents. The cited studies are above.

A fragment of human growth hormone (residues 176-191) studied for fat metabolism.

AOD-9604 research: what the studies have looked at

This page summarises the published research on AOD-9604, for reference. It states plainly what the studies found, including that human obesity trials did not demonstrate the effect they set out to measure. It is not medical advice, and what we supply is a research chemical for laboratory use only.

What AOD-9604 is

AOD-9604 is a short fragment of the C-terminus of human growth hormone (residues 176-191). It was investigated as a possible anti-obesity agent. Its position is worth stating plainly: human obesity trials did not demonstrate efficacy, it is not an approved medicine, and it is on the World Anti-Doping Agency prohibited list. It is supplied here for laboratory research only.

What the studies investigated

Ng et al. (2000), Hormone Research 53(6):274. Obese Zucker rat. Investigated the effect on weight gain in an obese rodent model Source.

Heffernan et al. (2001), Endocrinology 142(12):5182. Obese and beta-3-knockout mice. Investigated lipid metabolism and a beta-3-adrenergic pathway Source.

Wilding et al. (2004), Current Opinion in Investigational Drugs 5(4):436. Review of clinical development. Reviewed the clinical development, in which human trials did not demonstrate efficacy Source.

Mechanism, as described in the literature

The literature describes AOD-9604 as a growth-hormone fragment studied for effects on fat metabolism through a beta-3-adrenergic pathway in obese rodents. When the compound was taken into human obesity trials, the reported result was that it did not produce the weight effect it was designed to test. That honest, negative human finding is part of the record and is stated here as such.

The material we supply

We supply AOD-9604 as a research chemical, released against a written specification with a batch certificate of analysis. It is not an approved medicine and is not for human or animal use. For the vial sizes, the price per mg and how to order, see the AOD-9604 compound page; the COA lookup pulls the certificate for any batch. The references above link to each study’s record; this summary is for research and educational reference only.